202401.22
How does the brain volume of people with eating disorders differ from that of healthy individuals? (Paper publication)
Posted in RESEARCH
It has been revealed that there are several neurological differences between people with eating disorders and healthy individuals. However, the reliability and reproducibility of previous studies were limited because of relatively small sample sizes. Therefore, this study aimed to gain more robust results by conducting multicenter study. Under the leadership of Dr. Atsushi Sekiguchi, National Center of Neurology and Psychiatry, MRI data from five centers (Chiba University, Kyushu University, Kyoto University, Tohoku University, and University of Occupational and Environmental Health) were analyzed.In Tohoku University, we collected the data by collaborating with Department of Psychosomatic Medicine, Tohoku University Hospital using MRI equipment at the Brain MRI Center of the Institute of Development, Aging, and Cancer. 32 researchers participated in the research and it is revealed which brain regions volume were reduced in patients and which were related to severity of symptoms.
The results were published as a paper "Systematic reduction of gray matter volume in anorexia nervosa, but relative enlargement with clinical symptoms in the prefrontal and posterior insular cortices: a multicenter neuroimaging study" in Molecular Psychiatry (Hamamoto). https://doi.org/10.1038/s41380-023-02378-4
It has been revealed that there are several neurological differences between people with eating disorders and healthy individuals. However, the reliability and reproducibility of previous studies were limited because of relatively small sample sizes. Therefore, this study aimed to gain more robust results by conducting multicenter study. Under the leadership of Dr. Atsushi Sekiguchi, National Center of Neurology and Psychiatry, MRI data from five centers (Chiba University, Kyushu University, Kyoto University, Tohoku University, and University of Occupational and Environmental Health) were analyzed. In Tohoku University, we collected the data by collaborating with Department of Psychosomatic Medicine, Tohoku University Hospital using MRI equipment at the Brain MRI Center of the Institute of Development, Aging, and Cancer. 32 researchers participated in the research and it is revealed which brain regions volume were reduced in patients and which were related to severity of symptoms.
The results were published as a paper "Systematic reduction of gray matter volume in anorexia nervosa, but relative enlargement with clinical symptoms in the prefrontal and posterior insular cortices: a multicenter neuroimaging study" in Molecular Psychiatry (Hamamoto).
https://doi.org/10.1038/s41380-023-02378-4